Bioinformatic Approaches for Fungal Omics

Bioinformatic Approaches for Fungal Omics

Fungal omics (including genomics, transcriptomics, metabo-lomics, proteomics, and lipidomics) are now broadly applied to help understand both the basic fungal biology and associated applications. Due to the advantages of the rapid development of Next-Generation Sequencing (NGS) technologies, bioinformatics algorithms, and the relatively smaller sizes of fungal genomes compared with other eukary...

Bioinformatic approaches for genome finishing

Systems Biology Approaches for Host–Fungal Interactions: An Expanding Multi-Omics Frontier

Opportunistic fungal infections are an increasing threat for global health, and for immunocompromised patients in particular. These infections are characterized by interaction between fungal pathogen and host cells. The exact mechanisms and the attendant variability in host and fungal pathogen interaction remain to be fully elucidated. The field of systems biology aims to characterize a biologi...

Bioinformatic Approaches for Predicting substrates of Proteases

Proteases have central roles in "life and death" processes due to their important ability to catalytically hydrolyze protein substrates, usually altering the function and/or activity of the target in the process. Knowledge of the substrate specificity of a protease should, in theory, dramatically improve the ability to predict target protein substrates. However, experimental identification and ...

Using “omics” and integrated multi-omics approaches to guide

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